Stand: 01.11.2008
Produktprofil:
Schoppmann A., Weber A., Nikolic N., Pösler G., Varadi K., Turecek P.
Ceprotin - A Highly Purified Protein C Concentrate: Product Characterization
XVIIIth Congress of the International Society on Thrombosis and Haemostasis, Paris, 06.-12.07.2001
Gritsch H., Weber A., Schoppmann A., Turecek P.
Stability of CEPROTIN, Human Protein C Concentrate, for Use in Continuous Infusion
XXth Congress of the International Society of Thrombosis and Hemostasis, Sydney, 06.-12.08.2005
Weber A., Nikolic N., Hondl F., Schoppmann A., Linnau Y.
In Vitro Evaluation of Stability of Protein C Concentrate for Continuous Infusion
XVIIth Congress of the International Society on Thrombosis and Haemostasis, Washington, 14.-21.08.1999
Tierexperimentelle Studien:
Muchitsch E., Schwarz H., Varadi K., Esmon C., Mancuso G., Teti G.
Effect of Human Plasma-Derived Protein C and Murine Recombinant Protein C on Severe Neonatal Sepsis in Mice
25th Symposium on Intensive Care and Emergency Medicine, Brüssel, 21.-25.03.2005
Varadi K., Turecek P., Gritsch H., Schick E., Baumgartner B., Muchitsch E.
Kinetics of in vivo Activation of Protein C in Healthy Animals
XXth Congress of the International Society of Thrombosis and Hemostasis, Sydney, 06.-12.08.2005
Schwerer angeborener Protein C-Mangel:
Auberger K.
Evaluation of a new protein-C concentrate and comparison of protein-C assays in a child with congenital protein-C deficiency
Ann. Hematol. 64:146-151 (1992)
Baliga V., Thwaites R., Tillyer M., Minford A., Parapia L., Allgrove J.
Homozygous protein C deficiency - management with protein C concentrate
Eur. J. Pediatr. 154: 534-538 (1995)
Beeg T., Mentzer D., Martinez I., Zwinge B., Scharrer I., Kreuz W.
Homozygoter Protein C-Mangel: Ein Fallbericht - Klinik, Diagnostik und Therapie mit einem Protein C-Konzentrat
In: 24. Hämophilie-Symposion Hamburg 2003, S. 372-375
I. Scharrer, W. Schramm (eds)
Springer Verlag Berlin Heidelberg 1994
Beneke H., Langer C., Struve S., Griesshammer M., Oldenburg J., Grünewald M.
Pregnancy of a Libanese Woman With Homozygous Protein C Deficiency
XXth Congress of the International Society of Thrombosis and Hemostasis, Sydney, 06.-12.08.2005
Christoph J., Heiming R.
Homozygoter Protein C-Mangel, Diagnostische und Therapeutische Aspekte
Monatsschr. Kinderheilkunde 142 (Suppl. 1): P414 (1994)
Conard J., Bauer K., Gruber A., Griffin J., Schwarz H., Horellou M., Samama M., Rosenberg R.
Normalization of Markers of Coagulation Activation With a Purified Protein C Concentrate in Adults With Homozygous Protein C Deficiency
Blood 82: 1159-1164 (1993)
Dreyfus M., Masterson M., David M., Rivard G., Müller F., Kreuz W., Beeg T., Minford A., Allgrove J., Cohen J., Christoph J., Bergmann F., Mitchell V., Haworth C., Nelson K., Schwarz H.
Replacement Therapy with a Monoclonal Antibody Purified Protein C Concentrate in Newborns with Severe Congenital Protein C Deficiency
Sem. Thromb. Hemost. 21: 371-381 (1995)
Dreyfus M., Magny J., Bridey F., Schwarz H., Planché C., Dehan M., Tchernia G.
Treatment of Homozygous Protein C Deficiency and Neonatal Purpura Fulminans with a Purified Protein C Concentrate
NEJM 325: 1565-1568 (1991)
Escuriola-Ettingshausen C., Aumann V., Auberger K., Boomgaars L., Cano J., Gomez Gomez N., Hertfelder H., Schramm W., Spannagl M., Wehinger H., Tonetta S., Ehrlich H., Moritz B., Kreuz W.
Protein C concentrate (human) in asymptomatic patients with homozygous or double heterozygous congenital protein C deficiency: interim analysis of a pharmacokinetic study
44. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH), Freiburg,
16.-19.02.2000
Fernandez-Burriel Tercero, M., Molines Honrubia A., Sala Serra N., Negrin Lopez M., Corral Seijas J., Gomez-Casares M.
Severe clinical presentation of protein C deficiency in a type I/II compound heterozygote newborn
Thromb. Haemost. 94:216-218 (2005)
Fields P., Jaffer H., Owens D., Lee C., Pasi K., Hoffbrand A.
Use of Protein C Concentrate to Treat Severe Homozygous Protein C Deficiency
Brit. J. Haematol. 87 (Suppl.1): A 702 (1994)
Gross J., Matiba B., Stephan B., Pindur G., Mörsdorf S., Seyfert U., Wenzel E.
Perioperative Substitution bei einem 57-jährigen Patienten mit Protein C-Mangel und endoskopischer Cholecystektomie
In: 29. Hämophilie-Symposion Hamburg 1998, S. 177-180
I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 2000
Hattenbach L., Beeg T., Kreuz W., Zubcov A.
Ophthalmic Manifestation of Congenital Protein C Deficiency
Journal of AAPOS 3: 188-190 (1999)
Hertfelder H., Popov-Cenic S., Reitsma P., Riekel B.
Pharmacokinetics of Protein C in Protein C-Deficient Patients
XIIIth Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, 30.06.-06.07.1991, A 1842
Hertfelder H., Kornbrust A., Effenberger W., Hanfland P., Lentze M.
Pharmacokinetics of Protein C Concentrate CEPROTIN in Treatment of a Child with Severe Homozygous Protein C Deficiency
46. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH), Erfurt,
20.-23.02.2002, A 119
Hertfelder H., Kornbrust A., Pannier-Fischer M., Rabe E., Hanfland P., Lentze M.
Treatment of thrombotic complications and prophylactic use of protein C concentrate in two homozygous protein C deficient patients during surgery
J. Thromb. Haemostas. Suppl., July 2003, A P1022
Hertfelder H., Pavlova A., Kamil D., Horneff S., Gembruch U., Bartmann P., Oldenburg J., Müller A., Franz A., Heep A.
Postnatal management of a severely protein C deficient newborn by protein C concentrate substitution
51. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH), Dresden,
21.-24.02.2007, A 21
Kemahli S., Gandrille S., Alhenc-Gelas M., Aiach M., Cin S.
Homozygous protein C deficiency with a double variant His 202 to Tyr and Ala 346 to Thr
XVIth Congress of the International Society on Thrombosis and Haemostasis, Florenz,
06.-12.06.1997, PS-1690.
Knoebl P.
Severe congenital protein C deficiency: the use of protein C concentrates (human) as replacement therapy for life-threatening blood-clotting complications
Biologics: Targets & Therapy 2:1-12 (2008)
Mathias M., Khair K., Burgess C., Liesner R.
Subcutaneous Administration of Protein C Concentrate
Pediatric Hematology and Oncology 21:551-556 (2004)
Minford A., Parapia L., David M., Gomez Gomez N., Sanz-Rodriguez C., Bond M.
Treatment of Homozygous Protein C Deficiency with Subcutaneous Protein C Concentrate - Experience from Four Centres
XVIIth Congress of the International Society on Thrombosis and Haemostasis, Washington,
14.-21.08.1999
Minford A., Parapia L., Stainforth C., Lee D.
Treatment of homozygous protein C deficiency with subcutaneous protein C concentrate
Brit. J. Haematol. 93: 215-216 (1996)
Minford A., Parapia L.
Homozygous Protein C Deficiency in an Affected Fetus – Is There a Case for Early Elective Delivery?
XXth Congress of the International Society of Thrombosis and Hemostasis, Sydney, 06.-12.08.2005
Monagle P., Newall F., Ignjatovic V., Sarkaar S., Campbell J., Savoia H.
Homozygous Protein C Deficiency: Subcutaneous Protein C Replacement is Effective as Salvage or Maintenance Therapy
44th Annual Meeting American Society of Hematology, Philadelphia, 07.-10.12.2002
Monagle P., Ignjatovic V., Newall F., Savoia H., Campbell J., Barnes C., Hardikar W., Smith A.
Multi Modal Management of Purpura Fulminans due to Homozygous Protein C Deficiency
XXth Congress of the International Society of Thrombosis and Hemostasis, Sydney, 06.-12.08.2005
Moritz B., Rogy S., Tonetta S., Engl W., Najm R., Schwarz H., Gomperts E., Ehrlich H.
The Efficacy and Safety of Protein C Concentrate (Human) Vapor-Heated in the Treatment of Severe Congenital Protein C Deficiency with or without Purpura Fulminans
42nd Annual Meeting American Society of Hematology, San Francisco, 01.-05.12.2000
Müller F., Ehrenthal W., Hafner G., Schranz D.
Purpura fulminans in severe congenital protein C deficiency: monitoring of treatment with protein C concentrate
Eur. J. Pediatr. 155: 20-25 (1996)
Pinilla I., Gil-Fernandez J., Gomez Gomez N., Cano J., Pajuelo F., Sanchez S., Fernandez-Ranada J., Schwarz H.
Homozygous protein C deficiency in a newborn: One-year of follow up receiving protein C concentrate and oral anticoagulation
XVIth Congress of the International Society on Thrombosis and Haemostasis, Florenz,
06.-12.06.1997, PS-1692.
Salonvaara M., Kuismanen K., Mononen T., Riikonen P.
Diagnosis and treatment of a newborn with homozygous protein C deficiency.
Acta Paediatr. 93: 137-139 2004
Sanz-Rodriguez C., Gil-Fernandez J., Zapater P., Pinilla I., Granados E., Gomez-G. de Soria V., Cano J., Sala N., Fernandez-Ranada J., Gomez Gomez N.
Long-term Management of Homozygous Protein C Deficiency: Replacement Therapy with Subcutaneous Purified Protein C Concentrate
Thromb. Haemost. 81: 887-890 (1999)
Tcheng W., Dovat S., Gurel Z., Donkin J., Wong W.:
Severe Congenital Protein C Deficiency: Description of a New Mutation and Prophylactic Protein C Therapy and In Vivo Pharmacokinetics
J. Pediatr. Hematol. Oncol. 30:166-171 (2008)
Orale Antikoagulation:
De Stefano V., Mastrangelo S., Schwarz H., Pola P., Flore R., Bizzi B., Leone G.
Replacement Therapy with a Purified Protein C Concentrate during Initiation of Oral Anticoagulation in Severe Protein C Congenital Deficiency
Thromb. Haemost. 70: 247-249 (1993)
Gil-Fernandez J., Gomez Gomez N., Cano J., Torrelo A., Fernandez-Ranada J.
Homozygous Protein C Deficiency in a Newborn: Successful Treatment with Protein C Concentrate and Oral Anticoagulation
Haemostasis 26 (Suppl.3): A 161 (1996)
Guerin V., Ryman A., Pedespan J., Freyburger G., Calvora R.
Oral Anticoagulant Therapy Initiation in a Severely Protein C Deficient Infant: Use of Human Protein C Concentrate
45th Annual Meeting American Society of Hematology, San Diego, 2003
Kemkes-Matthes B.
Einleitung einer Kumarintherapie unter Substitution mit Protein C-Konzentrat bei einem ungewöhnlichen Fall von Protein C-Mangel
In: 22. Hämophilie-Symposion Hamburg 1991, S. 293-298
G. Landbeck, I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 1992
Lewandowski K., Zawilska K.
Protein C Concentrate in the Treatment of Warfarin-Induced Skin Necrosis in the Protein C Deficiency
Thromb. Haemost. 71: 395 (1994)
Muntean W., Finding K., Gamillscheg A., Schwarz H.
Multiple Thromboses and Coumarin-induced Skin Necrosis in a Child With Anticardiolipin Antibodies: Effects of Protein C Concentrate Administration
XIIIth Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, 30.06.-06.07.1991
Rogy S., Moritz B., Tonetta S., Najm R., Gomperts E., Ehrlich H.
The Efficacy and Safety of CEPROTIN, a Highly Purified Protein C Concentrate, in the Treatment of Purpura Fulminans and Coumarin-Induced Skin Necrosis in Patients with Protein C Deficiency
XVIIIth Congress of the International Society on Thrombosis and Haemostasis, Paris, 06.-12.07.2001
Schellong S., Siegert G., Hakenberg O., Kruse H., Konrad C., Wirth M., Schröder H.
Devastating hypocomplementemic urticarial vasculitis in a patient with type IIb protein C deficiency
44. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH), Freiburg,
16.-19.02.2000
Schramm W., Spannagl M., Bauer K., Rosenberg R., Birkner B., Linnau Y., Schwarz H.
Treatment of Coumarin-Induced Skin Necrosis with a Monoclonal Antibody Purified Protein C Concentrate
Arch. Dermatol. 129:753-756(1993)
Wermes C., Bergmann F., Reller B., Sykora K.
Severe protein C deficiency and aseptic osteonecrosis of the hip joint: a case report
Eur. J. Pediatr. 158 (Suppl.3): S159-S161(1999)
Schwangerschaft:
Barnes C., Newall F., Higgins S., Carden S., Monagle P.
Perinatal Management of Patients at High Risk of Homozygous Protein C Deficiency
Thromb. Haemost. 88:370-371(2002)
Kuismanen K., Salonvaara M., Mononen T., Riikonen P.
A Newborn with Neonatal Purpura Fulminans in a Family with Hereditary Type II Protein C Deficiency
XVIIIth Congress of the International Society on Thrombosis and Haemostasis, Paris, 06.-12.07.2001
Manco-Johnson M., Nuss R.
Protein C Concentrate Prevents Peripartum Thrombosis
Am. J. Hematol. 40: 69-70 (1992)
Murphy Goodwin T., Gazit G., Gordon E.
Heterozygous Protein C Deficiency Presenting as Severe Protein C Deficiency and Peripartum Thrombosis: Successful Treatment With Protein C Concentrate
Obstetrics & Gynecology 86(4): 662-664 (1995)
Richards E., Makris M. Preston F.
The successful use of protein C concentrate during pregnancy in a patient with type I protein C deficiencvy, previous thrombosis and recurrent fetal loss
Brit. J. Haematol. 98: 660-661(1997)
Thrombosen:
Dinger J., Knöfler R., Müller D., Hahn G., Goebel P., Siegert G.:
Neonatal protein C deficiency after massive thromboembolic event of the right upper limb - treatment with protein C concentrate
in: 33rd Hemophilia Symposium Hamburg 2002, p.110-114
I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 2004
Favier R., Deschamps A., Belhocine R., Ankri A., Costil J., De Moerloose P.
Simultaneous administration of antithrombin III and protein C concentrates for the treatment of a devastating coagulopathy in a child
Hematol. Cell Ther. 40: 67-70 (1998)
French J., Montgomery R., Foster P., Endres-Brooks J., Pietryga D., Schwarz H., Gill J.
Protein C Concentrate Therapy in a Protein C Deficient Patient With Superior Vena Cava Thrombosis Following Bone Marrow Transplantation
Blood 82 (Suppl. 1): A 1577 (1993)
Mori P., Boeri E., Molinari A., Tasonni V., Dodero P., Caffarena P., Amato S., Odino S.
Portal Vein Thrombosis in Newborn Due to Protein C Deficiency
Brit. J. Haematol. 87 (Suppl. 1): A 315 (1994)
Schneppenheim R., Harps E., Helmke K., Kreuz W., Hellwege H.
Erfolgreicher Einsatz eines Protein C-Konzentrats (CEPROTIN) bei Thrombose-Patienten mit heterozygotem Protein C-Mangel
32. Hämophilie-Symposion, Hamburg, 09.-10.11.2001
Tardy-Poncet B., Rayet I., Damon G., Alhenc-Gelas M., Dutour N., Lavocat M.
Protein C Concentrates in a Neonate with a Cerebral Venous Thrombosis due to Heterozygous Type I Protein C Deficiency
Thromb. Haemost. 85: 1118-1119 (2001)
Urban J., Hoch B., Kurnik K., Heinrich M.
Thrombose der A. femoralis superficialis rechts im Rahmen eines Waterhouse-Friderichsen-Syndroms: Erfolgreiche Lysetherapie mit rt-PA unter Substitution von Protein C
29. Jahrestagung Ges. Neonatol. Päd. Intensivmedizin, Köln, 03.-05.07.2003
Zeitler P., Mingers A.
Einsatz von Protein-C-Konzentrat bei heterozygotem Protein-C-Mangel und wachsendem Thrombus der Vena cava inferior
In: 26. Hämophilie-Symposion Hamburg 1995
I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 1997
Zyschka A., Escuriola Ettingshausen C., Klarmann D., Heller C., Becker S., Müller W., Figura S., Zubcov A., Klingebiel T.
Administration of Protein C Concentrate (Ceprotin, Baxter) in Purpura Fulminans as the First Clinical Manifestation of Galactosemia
in: 33rd Hemophilia Symposium Hamburg 2002, p.201-204
I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 2004
Venous Occlusive Disease (VOD):
Eber S., Gungor T., Veldman A., Sykora K., Scherer F., Fischer D., Grigull L.
Favorable response of pediatric stem cell recipients to human protein C concentrate substitution for veno-occlusive disease
Pediatric Transplantation 11:49-57 (2007)
Kentouche K., Mentzel H., Hermann J., Zintl F.
Protein C Concentrate for the Treatment of Veno Occlusive Disease in a boy with Nephroblastoma
in: 34th Hemophilia Symposium Hamburg 2003, p.304-306
I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 2005
Kreuz W., Veldman A., Pötzsch B., Scharrer I., Martin H., Hoelzer D.
Treatment of veno occlusive disease after bone marrow transplantation: Continuous infusion of recombinant tissue plasminogen activator and simultaneous infusion of Protein C
42. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH), Frankfurt,
25.-28.02.1998
Schüler A., Gulba D., Sosada M., Ringe B., Pichlmayr R., Manns M.
Prevention of Postoperative Thromboembolic Complications in a Patient with Budd-Chiari Syndrome and Acquired Protein C Deficiency by Short-Term Administration of Protein C Concentrates
Fibrinolysis 9 (Suppl. 1): 129-132 (1995)
Sepsis / Infektionen:
Alberio L., Lämmle B., Esmon C.
Protein C Replacement in Severe Meningococcemia: Rationale and Clinical Experience
CID 32: 1338-1346 (2001)
Baratto F., Michielan F., Meroni M., Dal Palù, A., Boscolo A., Ori C.
Protein C concentrate to restore physiological values in adult septic patients
Intensive Care Med. 34:1707-1712 (2008).
Beeg T., Kreuz W., Joseph-Steiner J., Scharrer I., Kornhuber B.
Protein-C-Konzentrat zur Therapie von Protein-C-Mangelzuständen im Neugeborenenalter
In: 25. Hämophilie-Symposion Hamburg 1994
I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 1996
Bendiks M., Schütt S., Neumann R., Kohl M.
Protein C-Behandlung eines Patienten mit Meningokokkensepsis und drohender Nekrose der Nase
Ellipse 19 (2): 39-40 (2003)
Blatny J., Klimovic M., Sterba J., Habanec T., Penka M.
Non-activated protein C (Ceprotin) – successful treatment of sepsis and multi-organ failure (MOF) not only in children with malignancy
36. Hämophilie-Symposion, Hamburg, 18.-19.11.2005
Clarke R., Johnston J., Mayne E.
Meningococcal septicaemia: treatment with protein C concentrate
Intensive Care Med. 26: 471-473 (2000)
Escuriola-Ettingshausen C., Veldmann A., Beeg T., Schneider W., Jäger G., Kreuz W.
Replacement Therapy with Protein C Concentrate in Infants and Adolescents with Meningococcal Sepsis and Purpura Fulminans
Sem. Thromb. Hemost. 25: 537-541 (1999)
Gerson W., Dickerman J., Bovill E., Golden E.
Severe Acquired Protein C Deficiency in Purpura Fulminans Associated With Disseminated Intravascular Coagulation: Treatment With Protein C Concentrate
Pediatrics 91: 418-422 (1993)
Gualandi F., Mori P., Occhini D., Di Grazia C., Dominietto A., Raiola A., Bacigalupo A.
The Use of ‘Protein C’ in Allogeneic Bone Marrow Transplantation Patients
Pathophysiol. Haemost. Thromb. 33(suppl 1):77-104(2003)
Gutdeutsch P.
Anwendung von Protein C-Konzentrat bei Kindern mit Meningokokkensepsis
Ellipse 21:32-38 (2005)
Kauppila M., Rasi V., Remes K., Voipio-Pulkki L., Arola O.
Protein C Treatment in Severe Sepsis
Nordik Förening för Hematologi, 28e Vårmötet, Helsingfors, 22.-24.05.1997
König B., Müller M., Radke M.
Sepsistherapie mit Protein C im Kindesalter
Z. Geburtsh. Neonatol. 208(Suppl. 1):S1-S88(2004)
Kreuz W., Veldman A., Fischer D., Schlösser R., Rettwitz-Volk W., Escuriola-Ettingshausen C.
Neonatal Sepsis: A Challenge in Hemostaseology
Sem. Thromb. Hemost. 25: 531-535 (1999)
Maak B., Dänhardt C., Kochhan L., Heuchel P., Harwardt B.
Purpura fulminans in a boy with preexistent deficiencies of multiple coagulation factors and protein C
48. Jahrestagung GTH, Hamburg, 25.-28.02.2004
Hämostaseologie 1:A 47 (2004)
Makris P., Girtovitis F., Papadopoulos A., Tamiolaki M., Kosmidou M., Pythara E.
DIC Treatment. The Role of Protein C (PC)
13th Panhellenic Congress of Haematology, 2002
Ramser M., Kühne T., Lütschg J., Hammer J.
Does the Lack of a Large Trial Justify to Say No to Protein C in Children With Meningococcal Sepsis?
Jahreskongr. Schweiz. Ges. Pädiatrie (SGP), Davos, 26.-28.06.2003
Reetz M., Laske G., Schunck K., Brosch U.
Anwendung von Protein C bei einem 10 Jahre alten Mädchen mit Meningokokkensepsis
8. Deutscher Interdisziplinärer Kongress für Intensivmedizin und Notfallmedizin (DIVI), 2006
Repas-Humpe L., Lenz E., Lakomek M., Polster T., Unterhalt M., Schröter W., Eber S.
Erfolgreiche Protein-C-Substitution bei familiär gehäufter Varizellenassoziierter Purpura fulminans
In: 27. Hämophilie-Symposion Hamburg 1996
I. Scharrer, W. Schramm (eds.)
Springer-Verlag Berlin Heidelberg 1998
Rintala E., Kauppila M., Seppälä O., Voipio-Pulkki L., Pettilä V., Rasi V., Kotilainen P.
Protein C substitution in sepsis associated purpura fulminans
Crit. Care Med. 28: 2373-2378 (2000)
Rivard G., David M., Farrell C., Schwarz H.
Treatment of purpura fulminans in meningococcemia with protein C concentrate
J. Pediatrics 126: 646-652 (1995)
Ruffini E., Osimani P., Jorini M., Cordiali R., Pagni R., De Benedictis F.
Treatment of purpura fulminans with protein C concentrate: a further scientific evidence
Ital. J. Pediatr. 30:169-173(2004)
Sasse M., Kirschstein M., Köditz H., Seidenmann K., Wessel A.
A network-system for the treatment of pediatric septic shock
27th International Symposium on Intensive Care and Emergency Medicine, Brüssel, 27.-20.03.2007
Schellongowski P., Bauer E., Holzinger U., Staudinger T., Frass M., Laczika K., Locker G., Quehenberger P., Rabitsch W., Schenk P., Knöbl P.
Treatment of adult patients with sepsis-induced coagulopathy and purpura fulminans using a plasma-derived protein C concentrate (Ceprotin)
Vox Sanguinis 90:294-301 (2006)
Silvani P., Camporesi A., Licari E., Wolfler A.
Use of protein C concentrate in pediatric patients with sepsis
Minerva Anestesiologica 71:373-378 (2005)
Smith O., White B.
Annotation: Infectious Purpura Fulminans: Diagnosis and Treatment
Brit. J. Haematol. 104: 202-207 (1999)
Veldman A., Fischer D., Schneider W., Kreuz W.
Human protein C concentrate in the treatment of septic children and neonates
15th Annual Congress European Society of Intensive Care Medicine, Barcelona, 29.09.-02.10.2002
White B., Livingstone W., Murphy C., Hodgson A., Rafferty M., Smith O.
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia
Blood 96: 3719-3724 (2000)
Hämolytisch urämisches Syndrom (HUS):
Sasse M., Pape L., Koeditz H., Wessel A., Seidemann K., Thomas J., Brent B.
Human protein C concentrate in the treatment of haemolytic uremic syndrome
27th International Symposium on Intensive Care and Emergency Medicine, Brüssel, 27.-20.03.2007
Protein C-Aktivierung:
De Kleijn E., De Groot R., Hack E., Mulder P., Engl W., Moritz B., Joosten K., Hazelzet J.
Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study
Crit. Care Med. 31 (6): 1839-1847 (2003)
Galligan L., Livingstone W., Volkov Y., Hokamp K., Murphy C.
Characterization of protein C receptor expression in monocytes
Brit. J. Haematol. 115: 408-414 (2001)
Hassouna H., Quinn C.
Proteolysis of protein C in pooled normal plasma and purified protein C by activated protein C (APC)
Biophysical Chemistry 95: 109-124 (2002)
Sturn D., Kaneider N., Feistritzer C., Djanani A., Fukudome K., Wiedermann C.
Expression and function of the endothelial protein C receptor in human neutrophils
Blood 102: 1499-1505 (2003)
Diagnostik:
Bastian S.
Protein C-Diagnostik - Methoden, Interpretation und Limitationen
Ellipse 18: 11-16 (2002)
Cvirn G., Gallistl S., Muntean W.
Effects of Antithrombin and Protein C on Thrombin Generation in Newborn and Adult Plasma
Thrombosis Research 93: 183-190 (1999)
Lauterbach R., Pawlik D., Radziszewska R., Wozniak J., Rytlewski K.
Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns
Eur. J. Pediatr. DOI 10.1007/s00431-006-0139-7 (2006)
Shorr A., Bernard G., Dhainaut J., Russell J., Macias W., Nelson D., Sundin D.
Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome
Critical Care 2006, 10:R92
Von Pape K., Schwuchow J., Aland E., Bohner J.
Laborparameter als prognostische Indikatoren des SIRS und der Sepsis
48. Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH), Hamburg, 25.-28.02.2004
Gerinnungsfaktoren und Inhibitoren bei Neonaten:
Williams M., Chalmers E., Gibson B.
Guideline: The Investigation and Management of Neonatal Haemostasis and Thrombosis
Brit. J. Haematol. 119: 295-309 (2002)
Übersichtsarbeiten:
Knoebl P.
Blood Coagulation and Inflammation in Critical Illness: The Importance of the Protein C Pathway
UNI_MED Verlag 2008
Knoebl P.
Human Protein C Concentrates for Replacement Therapy in Congenital and Acquired Protein C Deficiency
Drugs of Today 44:429-441 (2008)
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